Line-up for i-to-i Innovation Hub 2023

Alder Hey Children's NHS Foundation Trust, UK

The Little Hearts at Home™ remote patient monitoring platform enables newborns and infants with extremely high-risk congenital heart disease, such as hypoplastic left heart patients (with a single working ventricle) to receive proactive and preventative care within the comfort of their homes.

The impact of Little Hearts at Home™ has seen the following:

· Reduction in inpatient length of stay, leading to a reduction in patient waiting lists.
· Efficiencies from the freeing up of clinical resources and hospital beds.
· Reduction in emergency admissions.
· Proactive and preventative care coordination between the clinical and community teams.
· Increase in clinical assurance.
· Improved patient experience.
· Decrease in the carbon footprint of clinical staff and families.

Apollo Hospitals Enterprises Limited , India

Apollo Hospitals, forerunners in the use of technology to improve healthcare delivery, have deployed a 5G technology-enabled ambulance as part of Apollo's Comprehensive Connected Care Program. This transmits real-time data between the ambulance and the hospital while being linked to and monitored by both the central and local command centers. We have been able to provide care to patients in remote areas of Himachal Pradesh, Odisha and Tripura who are far from healthcare access since the launch of the tele-health services project in collaboration with Apollo remote healthcare, increasing the hospital's ability to reach patients during the critical "golden hour."

Connected ambulances are an innovation in the healthcare industry that are designed to improve patient care and outcomes. These ambulances are equipped with a variety of sensors and devices that allow them to transmit real-time data to a central monitoring system. This data can be used by medical professionals to provide remote support to paramedics, diagnose patients more quickly and accurately, and make better decisions about treatment. There are several identified needs that connected ambulances meet. First, they can help to improve patient care by providing paramedics with access to real-time medical advice from experts. This can be especially helpful in rural areas where there is limited access to medical care. Second, connected ambulances can help to reduce the time it takes to diagnose and treat patients. This is because medical professionals can review the patient's data and make recommendations before the ambulance even arrives at the hospital. Third, connected ambulances can help to improve patient outcomes by ensuring that they receive the right treatment at the right time. This can lead to shorter hospital stays, fewer complications, and lower costs. More specific demands met by the connected ambulances are reduced response times, improved diagnosis, enhanced communication, and increased safety. Overall, connected ambulances are a promising new innovation that has the potential to improve patient care and outcomes.

CoNEX Healthcare Pte Ltd (PreSAGE), Singapore

PreSAGE is a thermography-based sensor patient monitoring solution developed by Tan Tock Seng Hospital and Singapore-based CoNEX Healthcare. PreSAGE, powered by artificial intelligence and novel image processing techniques, boasts three key design features – non-contact, non-intrusive and privacy-preserving. As an image-based solution with high accuracy, the system does not generate any patient-identifiable-information (PII) and is a widely accepted solution in public and private hospitals, nursing homes and residential apartments. For inpatient environment, PreSAGE predicts bed-exits to keep patients safe. For residential homes, PreSAGE extends the automated remote monitoring capabilities to include fall detection and prediction. We are looking for collaboration partners to co-investigate new use-cases to transform the future of healthcare.

Doole Health, Spain

Doole is a Telemedicine and Telehealth Platform that emerged from a research project about the application of Telemedicine in old HIV infected patients.

Doole has been developed from patient and professional needs as a bottom up solution.

We pursue four objectives:

a. Patient empowerment
b. Holistic view and management of the patient
c. Improve clinical outcomes
d. Cost-effective

To achieve those goals we created CIMA Concept:

a. Communication – providing video call and instant messaging channel between patient and professional as well as between different levels of care.
b. Information – Tailored information provided to patients to increase their health literacy
c. Monitoring – Through a omnichannel strategy to avoid barriers, with an alarm system to enable a proactive management of the patients.
d. Adherence – with a gamified system to enhance adherence to treatment and to healthy habits

And we’re designed to be integrated with any Hospital Information System to provide a seamless experience.

Stanford Healthcare_HrTex, USA

HrtEx is a digital health web application that has been shown to reduce blood pressure and that aids clinicians to more effectively and efficiently manage hypertension with fewer health care resources. The system uses a Bluetooth-enabled blood pressure cuff to transmit blood pressure values and the digital hypertension management system notifies the provider when changes in blood pressure medications are needed based on a provider’s predetermined prescription tree summary.

Geneva University Hospitals, Switzerland

BILIFREE is a low-cost method for measuring total bilirubin, necessary for screening and monitoring jaundice in new-borns, and suitable for low-income countries. It responds to an important medical need: jaundice affects two-thirds of new-borns, many of which require treatment. Detectable and easily treatable by blue-light phototherapy, it is in most cases benign. Failure to diagnose and treat this disease can lead to brain-toxic complications, and even death.

Diagnosis is based on the level of total bilirubin in the blood of new-borns but unfortunately, laboratory costs are prohibitive for low-income countries, where hyperbilirubinemia therefore becomes a major cause of disabilities.

BILIFREE is a 3D-printed device for protected sedimentation of blood in a glass-tube allowing subsequent colorimetric reading of the supernatant. It requires less than 100 mcl of blood, no electricity or chemicals and is very low-cost. Validation against a gold standard is currently under way in the NICU of the Geneva University Hospitals. An AI-based precise colorimetric reading by smartphone is in development.

Karolinska University Hospital, Sweden

Hospital-at-Home and Home-Monitoring in a regional digital network: from highly specialized medicine to primary care. We have developed a regional monitoring platform and working routine for high-risk patients to be closely monitored outside the hospital. Innovative features include:

1) Monitoring platform with individualized sensor set-up

2) Seamless transfer between different caregivers and levels of care within greater Stockholm region

3) Link to electronic health record covering 90% of patients in Region Stockholm

4) Monitoring service center providing expert guidance

5) Scalability for larger patient volumes and other conditions

6) Development of smart algorithms for decision support

7) Focus on patient self-care

The innovation “Hospital-at-Home (HaH) and Home-Monitoring (HM) in a regional digital network” offers potential solutions to major actual and future health care challenges.

1) An increasing number of patients needs to be served by a decreasing number of health care professionals: HaH and HM allows to treat patients and to manage chronic medical conditions in the patient´s homes, thereby freeing up valuable hospital resources.

2) Patients with severe chronic disease have a high risk of re-hospitalization: continuous HM offers valuable tools for proactive care by providing early alerts of deterioration and enabling preemptive interventions to avoid further deterioration.

3) Outpatient clinics are overloaded and clinic visits demand time consuming transport and costly hospital resources: HM allows to exchange outpatient clinic visits by remote visits and an individualized scheduling of follow-up tailored to the severity of the patients medical condition.

4) The collaboration between different care givers is often hampered by the lack of shared medical information and outdated modes of communication. Our regional digital health network facilitates a seamless transfer of patients between different caregivers and levels of care.

5) Limited access to specialized care is a critical barrier to the implementation of guideline directed medical therapy (GDMT): remote consultations are an important measure to improve accessibility of specialized care.

6) Finally, and most importantly: patients need to take more responsibility for the treatment of their disease: HaH and HM greatly improve patient involvement and provide a platform for improved person-centered medicine.

Geneva University Hospital (HUG) - Pneumoscope: The Shazam® for lungs

Onescope stands at the forefront of respiratory diagnostics with our AI-driven tool, the Pneumoscope. Since 2019, we've joined forces with prestigious institutions like Geneva University Hospitals (HUG) and the Swiss Federal Institute of Technology of Lausanne (EPFL). Together, we've undertaken international clinical studies, analyzing hundreds of thousands of respiratory cycles from patients worldwide, spanning conditions from asthma to COVID-19.

Our dedicated research team at EPFL created DeepBreath, our proprietary AI algorithm renowned for its nearly 95% accuracy in identifying respiratory abnormalities and its sharp precision in diagnosing specific diseases, a breakthrough that garnered recognition in Nature's npj Digital Medicine series (June 2023).

Simultaneously, in partnership with the Engineering School of Geneva (HEPIA), we developed the Pneumoscope. This unique 3-in-1 medical device combines a digital stethoscope, oximeter, and thermometer, streamlining diagnostics, disease severity, and prioritizing efficiency. For user accessibility, we've coupled it with an intuitive mobile app which employs DeepBreath to furnish users with precise diagnostics and tailored care recommendations.

With 4 years of meticulous development behind us, Onescope is ready to step in the process of product validation and regulatory compliance.

Hospital da Luz, Portugal

Innovative onboarding approach

Hospital da Luz Learning Health (HL LH) is a company from Luz Saúde - one of the largest health care groups in the Portuguese market - dedicated to the advanced training of healthcare professionals, promoting and disseminating the best and most innovative practices in the health care sector, as well as developing research and innovation.

This mission allows HL LH to contribute to the progression of the state of the art in the health care sector, namely through the implementation of new practices and methodologies, the revision and restructuration of processes, the adoption of new technologies, the creation of new products and development of technological decision support tools and solutions.

To support innovators, and innovation, HL LH provides a center of competences with three different environments – In Silico Lab, Simulation Lab and Living Lab – and promotes the adoption of the most emerging practices in this sector, tests and validates the solutions it develops (or whose development it supports) before their introduction into the market, complying with all legal and ethical requirements associated with this activity..

UMG Data Hub, Cyprus

Data hub aggregating paramedical and fitness data to create personalized health plans

Modality Partnership, UK

As one of the largest community and primary care providers in the UK, we continuously seek innovative ways to improve our operations. Being early adopters of technology, we leveraged the pandemic as an opportunity to build solutions that enhance resilience and sustainability across our community outpatient services and 50 GP practices. We implemented Repeat Process Automation (RPA) solutions, alleviating operational pressures, increasing efficiency, reducing elective recovery backlogs and improving patient and staff satisfaction. We have experienced significant positive impact - realising £2.7 million in GP / administration time - which motivates us to continue advancing in the RPA space.

Patchwork Health, UK

Since 2016, Patchwork Health has been on a mission to make truly flexible and sustainable working a reality for all healthcare staff. Patchwork's end-to-end workforce management solution, developed in partnership with the National Health Service, makes flexible and collaborative working a reality across the healthcare system, opening up visibility of work to clinicians, breaking down silos and ensuring that the right person is working where they are needed the most, in or out-hospital settings. Built by a team of dedicated healthcare veterans, and co-created with the NHS, Patchwork's technology and services have been embraced by over 100 healthcare sites to date.

Patchwork offers a range of different solutions, including temporary staff banks, which enable organisations to source temporary staff from their own pool of approved workers; ‘collaborative staff banks’, which help healthcare organisations team up with others in the same region to widen and share their temporary staffing pools; an innovative new rostering solution which enables more flexible, sustainable staffing for permanent healthcare staff; and an Agency Manager which makes it easier for managers to select appropriate temporary staff from external agencies when necessary.

Patchwork Insights also provides managers with comprehensive data oversight, to monitor staffing trends, shift fill rates and pay rate escalations, and reliably plan ahead to prevent staffing gaps.

Uphill Health, Portugal

UpHill is a clinical pathway software that integrates with existing hospital information systems to automate tasks and bridge gaps in care. UpHill orchestrates care, allowing a comprehensive view of patients’ care journey progress which includes past data - from the EHR - and recommended next steps. The pathways are built on top of an evidence-based decision support system enhanced with automation - internal (EHR) and external (patient). UpHill is a medical device SaaS, compliant with relevant industry-standard certifications and GDPR. UpHill is HL7 interoperable and uses catalogues (SNOMED, LOINC, WHO, etc.) to ensure a standardised data interpretation among systems.

Validated ID, Spain

Validated ID simplifies and secures electronic signature and digital identity validation processes, and VIDsigner has been classified as one of Europe's ten best digital signature solutions for improving patient relationships.

As a Trust Service Provider Qualified by the EU and regulated by eIDAS, Validated ID provides various signature options for both on-site and remote situations: BIO, Remote, Centralized, E-Delivery. These options utilize cryptography and biometrics to guarantee the authenticity of the signer and the integrity of the signed documents.

At present, VIDsigner signatures have earned the trust of 3,000 clients, 300 partners, and 150 software providers for their user-friendliness and reliability. In addition, over 70 healthcare platforms integrate VIDsigner, with over 1,500 hospitals utilizing our various signature options.

Acurable, Spain

AcuPebble SA100 is a tiny, non-invasive medical device for the automated diagnosis of obstructive sleep apnoea. The award-winning patented technology behind AcuPebble is a breakthrough in respiratory medicine and the result of over a decade of research at Imperial College London and Acurable. The system uses contact acoustics to accurately extract multiple physiological parameters from a single sensor at the base of the neck, where it has direct access to cardiorespiratory functions, including airflow. Patients find the sensor very comfortable, ensuring a more natural sleep at home, and an automated, comprehensive sleep study report is provided directly to clinicians.

Quantitative Digitography, Stanford Medicine USA

Parkinson’s disease (PD) is the fastest growing neurological disorder, yet only 2% of physicians become neurologists, a stable percentage over more than a decade. People with PD (PWP) require the care of a neurologist but 50% of PWP do not have access to a neurologist, and those who do have an average interval between visits of 3 - 6 months. Evaluation of PD has required an in-person visit on overbooked schedules. Management of acute problems or complications of therapy result in back and forth phone calls and delays; verbal descriptions of complex symptoms may result in suboptimal therapy decisions. These critical unmet needs have resulted in increased numbers of emergency room (ER) and hospital admissions. QDG brings the health care provider (HCP) to the patient using its point of care remote, reliable symptom monitoring system. QDG empowers the HCP to make more accurate therapy management decisions based on objective data, sent in real time and accessed in the PWP’s electronic medical record (EMR). Point of care testing is prescribed by the HCP to monitor the response to therapy, to monitor symptoms in between visits, or as needed if symptoms worsen unexpectedly. A QDG test sent from the ER provides the on- or off-site neurology consultant the data to make therapy recommendations faster, reducing patient time spent in the ER and improving access to neurological care. QDG testing during inpatient stays provides more rapid therapy implementation thereby reducing the length of stay. 

X-trodes, Israel

X-trodes is a deep-tech company with a revolutionized technology that enables the next generation of medial grade electrophysiology in natural environment, strong IP and amazing team.

Backed by more than 10 years of academic research and scientifically validated patents, our products, provides medical grade multimodality measurements (EEG, ECG and EMG signals). This patented ultra-soft, dry, multi-electrode patch array system enables optimal conformity to the patients and real-time signals display.

The company has several strategic collaborations, over 30 ongoing commercial projects and its technology is accessible to researchers and scientists worldwide. Its product has been tested for safety, clinically validated.